Nucleic Acid (NA) based therapeutics are poised to disrupt modern medicine and augment
traditional pharmaceutics in a meaningful way. However, a key challenge to advancing NA …

During the past decades, extracellular vesicles (EVs) have emerged as an attractive drug
delivery system. Here, we assess their pre-clinical applications, in the form of a systematic …

The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

Extracellular vesicles (EVs) are biological nanoparticles with important roles in intercellular
communication, and potential as drug delivery vehicles. Here we demonstrate a role for the …

Most of the potential therapeutic agents capable to modulate the pathophysiology or treat
the neurological disorders and brain tumors are useless in the current modern and …

High-grade glioma is one of the most aggressive types of cancer with a low survival rate
ranging from 12 to 15 months after the first diagnosis. Though being the most common …

The safety issues like immunogenicity and unacceptable cancer risk of viral vectors for
DNA/mRNA vaccine delivery necessitate the development of non-viral vectors with no …

Drug delivery to the central nervous system (CNS) conferred by brain barriers is a major
obstacle in the development of effective neurotherapeutics. In this review, a classification of …

Extracellular vesicles, including exosomes and microvesicles, play a fundamental role in the
activity of the nervous system, participating in signal transmission between neurons and …

Effective drug delivery to the CNS to achieve the desired therapeutic response is a
significant challenge in the field of drug delivery. In central nervous system (CNS), blood …