Changes in glutathione content in liver diseases: an update

M Vairetti, LG Di Pasqua, M Cagna, P Richelmi… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH), a tripeptide particularly concentrated in the liver, is the most important
thiol reducing agent involved in the modulation of redox processes. It has also been …

Hepatitis B virus entry into cells

C Herrscher, P Roingeard, E Blanchard - Cells, 2020 - mdpi.com
Hepatitis B virus (HBV), an enveloped partially double-stranded DNA virus, is a widespread
human pathogen responsible for more than 250 million chronic infections worldwide …

Role of silymarin in cancer treatment: facts, hypotheses, and questions

T Koltai, L Fliegel - Journal of Evidence-Based Integrative …, 2022 - journals.sagepub.com
The flavonoid silymarin extracted from the seeds of Sylibum marianum is a mixture of 6
flavolignan isomers. The 3 more important isomers are silybin (or silibinin), silydianin, and …

Pathogenicity and virulence of Hepatitis B virus

YC Chuang, KN Tsai, JHJ Ou - Virulence, 2022 - Taylor & Francis
Hepatitis B virus (HBV) is a hepatotropic virus and an important human pathogen. There are
an estimated 296 million people in the world that are chronically infected by this virus, and …

Mechanistic insights into the pharmacological significance of silymarin

K Wadhwa, R Pahwa, M Kumar, S Kumar, PC Sharma… - Molecules, 2022 - mdpi.com
Medicinal plants are considered the reservoir of diverse therapeutic agents and have been
traditionally employed worldwide to heal various ailments for several decades. Silymarin is a …

Antiviral activities of silymarin and derivatives

CH Liu, A Jassey, HY Hsu, LT Lin - Molecules, 2019 - mdpi.com
Silymarin flavonolignans are well-known agents that typically possess antioxidative, anti-
inflammatory, and hepatoprotective functions. Recent studies have also documented the …

Hepatitis B virus entry into HepG2‐NTCP cells requires clathrin‐mediated endocytosis

C Herrscher, F Pastor, J Burlaud‐Gaillard… - Cellular …, 2020 - Wiley Online Library
Hepatitis B virus (HBV) is a leading cause of cirrhosis and hepatocellular carcinoma
worldwide, with 250 million individuals chronically infected. Many stages of the HBV …

Hepatitis B virus DNA integration: in vitro models for investigating viral pathogenesis and persistence

T Tu, H Zhang, S Urban - Viruses, 2021 - mdpi.com
Hepatitis B virus (HBV) is a globally-distributed pathogen and is a major cause of liver
disease. HBV (or closely-related animal hepadnaviruses) can integrate into the host …

Protective role of flavonoids quercetin and silymarin in the viral-associated inflammatory bowel disease: An updated review

E Zarenezhad, HT Abdulabbas, AS Kareem… - Archives of …, 2023 - Springer
Inflammatory bowel disease (IBD) is a chronic recurrent inflammation of the gastrointestinal
tract (GIT). IBD patients are susceptible to various infections such as viral infections due to …

The hepatitis B virus interactome: a comprehensive overview

E Van Damme, J Vanhove, B Severyn… - Frontiers in …, 2021 - frontiersin.org
Despite the availability of a prophylactic vaccine, chronic hepatitis B (CHB) caused by the
hepatitis B virus (HBV) is a major health problem affecting an estimated 292 million people …