Neuregulins: functions, forms, and signaling strategies

DL Falls - The EGF Receptor Family, 2003 - Elsevier
Publisher Summary This chapter focuses on neuregulins (NRGs) that are the signaling
proteins that mediate cell–cell interactions in the nervous system, heart, breast, and other …

Peripheral nerve regeneration and neurotrophic factors

G Terenghi - The Journal of Anatomy, 1999 - cambridge.org
The role of neurotrophic factors in the maintenance and survival of peripheral neuronal cells
has been the subject of numerous studies. Administration of exogenous neurotrophic factors …

Neuregulins promote survival and growth of cardiac myocytes: persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes

Y Zhao, DR Sawyer, RR Baliga, DJ Opel, X Han… - Journal of Biological …, 1998 - ASBMB
Neuregulins (ie neuregulin-1 (NRG1), also called neu differentiation factor, heregulin, glial
growth factor, and acetylcholine receptor-inducing activity) are known to induce growth and …

Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons

L Wen, YS Lu, XH Zhu, XM Li… - Proceedings of the …, 2010 - National Acad Sciences
Neuregulin 1 (NRG1) is a trophic factor thought to play a role in neural development. Recent
studies suggest that it may regulate neurotransmission, mechanisms of which remain …

Effects of short‐and long‐term Schwann cell denervation on peripheral nerve regeneration, myelination, and size

OAR Sulaiman, T Gordon - Glia, 2000 - Wiley Online Library
Poor functional recovery after peripheral nerve injury has been generally attributed to
inability of denervated muscles to accept reinnervation and recover from denervation …

Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases

KL Carraway III, JL Weber, MJ Unger, J Ledesma, N Yu… - Nature, 1997 - nature.com
The neuregulins (NRGs) are a family of multipotent epidermal-growth-factor-like (EGF-like)
factors that arise from splice variants of a single gene. They influence the growth …

Isoform-specific expression and function of neuregulin

D Meyer, T Yamaai, A Garratt… - …, 1997 - journals.biologists.com
Neuregulin (also known as NDF, heregulin, ARIA, GGF or SMDF), induces cell growth and
differentiation. Biological effects of neuregulin are mediated by members of the erbB family …

Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses

YZ Huang, S Won, DW Ali, Q Wang, M Tanowitz, QS Du… - Neuron, 2000 - cell.com
Neuregulins (NRGs) and their receptors, the ErbB protein tyrosine kinases, are essential for
neuronal development, but their functions in the adult CNS are unknown. We report that …

Nrg1/ErbB signaling networks in Schwann cell development and myelination

J Newbern, C Birchmeier - Seminars in cell & developmental biology, 2010 - Elsevier
Neuregulin-1 (Nrg1) provides a key axonal signal that regulates Schwann cell proliferation,
migration and myelination through binding to ErbB2/3 receptors. The analysis of a number of …

The neuregulin-I/ErbB signaling system in development and disease

S Britsch - 2007 - books.google.com
Neuregulins are EGF-like growth and differentiation factors that interact with tyrosine kinase
receptors of the ErbB family. Neuregulin signals are also involved in the development …