Senescent cells: a therapeutic target in cardiovascular diseases

M Suda, KH Paul, T Minamino, JD Miller, A Lerman… - Cells, 2023 - mdpi.com
Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

[HTML][HTML] Emerging frontiers in drug delivery with special focus on novel techniques for targeted therapies

L Yu, S Liu, S Jia, F Xu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
The management and treatment of disease are achieved via the use of pharmacologically
active substances or drugs. Drugs do not, however, have an intrinsic ability to be effective; …

NLRP3‐Dependent Crosstalk between Pyroptotic Macrophage and Senescent Cell Orchestrates Trauma‐Induced Heterotopic Ossification During Aberrant Wound …

J Li, X Wang, Z Yao, F Yuan, H Liu, Z Sun… - Advanced …, 2023 - Wiley Online Library
Heterotopic ossification (HO) represents an unwanted ossific wound healing response to the
soft tissue injury which caused catastrophic limb dysfunction. Recent studies established the …

Potential clinical implications of senotherapies for cardiovascular disease

M Suda, G Katsuumi, T Tchkonia, JL Kirkland… - Circulation …, 2024 - jstage.jst.go.jp
Aging is a major risk factor for cardiovascular diseases (CVDs) and accumulating evidence
indicates that biological aging has a significant effect on the onset and progression of CVDs …

Cellular Senescence as a Targetable Risk Factor for Cardiovascular Diseases: Therapeutic Implications: JACC Family Series

M Kumar, P Yan, GA Kuchel, M Xu - Basic to Translational Science, 2024 - jacc.org
The prevalence of cardiovascular diseases markedly rises with age. Cellular senescence, a
hallmark of aging, is characterized by irreversible cell cycle arrest and the manifestation of a …

Risk factors for instent restenosis of sirolimus-coated stents in coronary intervention for patients with unstable angina

D Liu, Z Xue, J Qi, L Yin, B Duan, L Wu, K Yang… - Scientific Reports, 2024 - nature.com
To investigate the instent restenosis rate of sirolimus-coated stents in percutaneous
coronary intervention (PCI) and risk factors for in-stent restenosis, patients with unstable …

[HTML][HTML] Is it time for a retinoic acid-eluting stent or retinoic acid-coated balloon? Insights from experimental studies of systemic and local delivery of retinoids

I Samara, AN Moulas, G Karanasiou… - Hellenic Journal of …, 2024 - Elsevier
Although the incidence of restenosis and stent thrombosis has substantially declined during
the last decades, they still constitute the two major causes of stent failure. These …

Systematically study the comprehensive performance of poly (L-lactic acid) drug-coated stent in vitro and in vivo during full degradation cycle

J Lv, L Chen, X Hu, R Sun, B Wang, J Cheng… - Materials Today …, 2025 - Elsevier
Abstract Poly (L-lactic acid)(PLLA) drug-coated stents are increasingly recognized for
treating arterial diseases, owing to their biocompatibility, mechanical strength, and drug …

CASP1 Gene Polymorphisms and BAT1-NFKBIL-LTA-CASP1 Gene–Gene Interactions Are Associated with Restenosis after Coronary Stenting

G Vargas-Alarcón, J Ramírez-Bello, MA Peña-Duque… - Biomolecules, 2022 - mdpi.com
In the present study, we evaluated the association of the BAT1, NFKBIL, LTA, and CASP1
single nucleotide polymorphisms and the gene–gene interactions with risk of developing …