In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

The molecular composition of presynaptic and postsynaptic neuronal terminals is dynamic,
and yet long-term stabilizations in postsynaptic responses are necessary for synaptic …

Information in a computer is quantified by the number of bits that can be stored and
recovered. An important question about the brain is how much information can be stored at a …

The structural organization of excitatory inputs supporting spike-timing-dependent plasticity
(STDP) remains unknown. We performed a spine STDP protocol using two-photon (2P) …

Recent evidence implicates glutamatergic synapses as key pathogenic sites in psychiatric
disorders. Common and rare variants in the ANK3 gene, encoding ankyrin-G, have been …

Identification and characterisation of novel targets for treatment is a priority in the field of
psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a …

Neurotransmission is critically dependent on the number, position, and composition of
receptor proteins on the postsynaptic neuron. Of these, α-amino-3-hydroxy-5-methyl-4 …

Dendritic spines are small subcompartments that protrude from the dendrites of neurons and
are important for signaling activity and synaptic communication. These subcompartments …

The proper spatial arrangement of organelles underlies many cellular processes including
signaling, polarization, and growth. Despite the importance of local positioning, the precise …

In the central nervous system, most excitatory post-synapses are small subcellular structures
called dendritic spines. Their structure and morphological remodeling are tightly coupled to …