Simple Summary The unfolded protein response (UPR) is the cells' way of maintaining the
balance of protein folding in the endoplasmic reticulum, which is the section of the cell …

The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …

The endoplasmic reticulum (ER) is a large, dynamic structure that serves many roles in the
cell including calcium storage, protein synthesis and lipid metabolism. The diverse functions …

The endoplasmic reticulum (ER) is a critical organelle for protein synthesis, folding and
modification, and lipid synthesis and calcium storage. Dysregulation of ER functions leads to …

A central function of the endoplasmic reticulum (ER) is to coordinate protein biosynthetic and
secretory activities in the cell. Alterations in ER homeostasis cause accumulation of …

The manner in which a newly synthesized chain of amino acids transforms itself into a
perfectly folded protein depends both on the intrinsic properties of the amino-acid sequence …

Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms
are poorly understood. Using cell culture and mouse models, we show that obesity causes …

Endoplasmic reticulum (ER) is the site of synthesis and folding of secretory proteins.
Perturbations of ER homeostasis affect protein folding and cause ER stress. ER can sense …

During cellular stresses, phosphorylation of eukaryotic initiation factor-2 (eIF2) elicits gene
expression designed to ameliorate the underlying cellular disturbance. Central to this stress …

Replicative cell division is an energetically demanding process that can be executed only if
cells have sufficient metabolic resources to support a doubling of cell mass. Here we show …