Neuroinflammation has positive and negative effects. This review focuses on the roles of
macrophage in the PNS. Transection of PNS axons leads to degeneration and clearance of …

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses
immersed in aberrant communication circuits that facilitate tumor growth and dissemination …

Nerve growth factor (NGF) is a neurotrophic protein essential for the growth, differentiation,
and survival of sympathetic and sensory afferent neurons during development. A substantial …

Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

Traumatic injury to peripheral nerves results in the loss of neural functions. Recovery by
regeneration depends on the cellular and molecular events of Wallerian degeneration that …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Nociceptive pain results from the detection of intense or noxious stimuli by specialized high-
threshold sensory neurons (nociceptors), a transfer of action potentials to the spinal cord …

In a large proportion of individuals nervous system damage may lead to a debilitating
chronic neuropathic pain. Such pain may now be considered a neuro-immune disorder …

The cytokine cascade in pain and inflammatory processes is a tremendously complex
system, involving glial, immune, and neuronal cell interactions. IL-1β is a pro-inflammatory …

Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …