The diverse cell types of an organ have a highly structured organization to enable their
efficient and correct function. To fully appreciate gene functions in a given cell type, one …

The mechanisms of cardiovascular diseases (CVDs) remain incompletely elucidated. Single-
cell RNA sequencing (scRNA-seq) has enabled the profiling of single-cell transcriptomes at …

Current transcriptomics technologies, including bulk RNA-seq, single-cell RNA sequencing
(scRNA-seq), single-nucleus RNA-sequencing (snRNA-seq), and spatial transcriptomics …

Metastasis is the major cause of lung cancer-related death, but the mechanisms governing
lung tumor metastasis remain incompletely elucidated. SE translocation (SET) is …

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and
senescent cells have emerged as key contributors to its pathogenesis. Senescent cells …

There is an increasing recognition of the crucial role of the right ventricle (RV) in determining
the functional status and prognosis in multiple conditions. In the past decade, the epigenetic …

Background Thoracic aortic dissection (TAD) is a life-threatening disease caused by an
intimal tear in the aorta. The histological characteristics differ significantly between the tear …

Spatial transcriptome technology acquires gene expression profiles while retaining spatial
location information, it displays the gene expression properties of cells in situ. Through the …

Arrhythmogenic cardiomyopathy is an inherited entity characterized by irregular cell–cell
adhesion, cardiomyocyte death and fibro-fatty replacement of ventricular myocytes, leading …

Acute myocarditis covers a wide spectrum of clinical presentations, from uncomplicated
myocarditis to severe forms complicated by hemodynamic instability and ventricular …