Assessing and advancing the safety of CRISPR-Cas tools: from DNA to RNA editing
CRISPR-Cas gene editing has revolutionized experimental molecular biology over the past
decade and holds great promise for the treatment of human genetic diseases. Here we …
decade and holds great promise for the treatment of human genetic diseases. Here we …
Biomolecular condensates and cancer
Malignant transformation is characterized by dysregulation of diverse cellular processes that
have been the subject of detailed genetic, biochemical, and structural studies, but only …
have been the subject of detailed genetic, biochemical, and structural studies, but only …
Endogenous DNA damage as a source of genomic instability in cancer
A Tubbs, A Nussenzweig - Cell, 2017 - cell.com
Genome instability, defined as higher than normal rates of mutation, is a double-edged
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …
sword. As a source of genetic diversity and natural selection, mutations are beneficial for …
Mechanisms underlying mutational signatures in human cancers
The collective somatic mutations observed in a cancer are the outcome of multiple
mutagenic processes that have been operative over the lifetime of a patient. Each process …
mutagenic processes that have been operative over the lifetime of a patient. Each process …
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
Although great progress has been made in the characterization of the off-target effects of
engineered nucleases, sensitive and unbiased genome-wide methods for the detection of …
engineered nucleases, sensitive and unbiased genome-wide methods for the detection of …
Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization
Nuclear actin-based movements have been shown to orchestrate clustering of DNA double-
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
strand breaks (DSBs) into homology-directed repair domains. Here we describe multiscale …
[HTML][HTML] HIV-1 integration landscape during latent and active infection
The barrier to curing HIV-1 is thought to reside primarily in CD4+ T cells containing silent
proviruses. To characterize these latently infected cells, we studied the integration profile of …
proviruses. To characterize these latently infected cells, we studied the integration profile of …
Different SWI/SNF complexes coordinately promote R-loop-and RAD52-dependent transcription-coupled homologous recombination
C Davó-Martínez, A Helfricht… - Nucleic Acids …, 2023 - academic.oup.com
The SWI/SNF family of ATP-dependent chromatin remodeling complexes is implicated in
multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF …
multiple DNA damage response mechanisms and frequently mutated in cancer. The BAF …
Structural variations in cancer and the 3D genome
F Dubois, N Sidiropoulos, J Weischenfeldt… - Nature Reviews …, 2022 - nature.com
Structural variations (SVs) affect more of the cancer genome than any other type of somatic
genetic alteration but difficulties in detecting and interpreting them have limited our …
genetic alteration but difficulties in detecting and interpreting them have limited our …
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond
Class-switch DNA recombination (CSR) of the immunoglobulin heavy chain (IGH) locus is
central to the maturation of the antibody response and crucially requires the cytidine …
central to the maturation of the antibody response and crucially requires the cytidine …