Small molecules in the treatment of COVID-19
S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
societies and economies. Until now, effective therapeutics against COVID-19 are in high …
The mechanisms of action of ivermectin against SARS-CoV-2—an extensive review
AK Zaidi, P Dehgani-Mobaraki - The Journal of antibiotics, 2022 - nature.com
Considering the urgency of the ongoing COVID-19 pandemic, detection of new mutant
strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as …
strains and potential re-emergence of novel coronaviruses, repurposing of drugs such as …
[PDF][PDF] Therapeutics and COVID-19: living guideline, 13 January 2023
World Health Organization - 2023 - apps.who.int
As of December 2022, there have been over 642 million confirmed cases of COVID-19 (10).
The pandemic has thus far claimed approximately 6.62 million lives (10). Vaccination is …
The pandemic has thus far claimed approximately 6.62 million lives (10). Vaccination is …
Microgliosis and neuronal proteinopathy in brain persist beyond viral clearance in SARS-CoV-2 hamster model
C Käufer, CS Schreiber, AS Hartke, I Denden… - …, 2022 - thelancet.com
Background Neurological symptoms such as cognitive decline and depression contribute
substantially to post-COVID-19 syndrome, defined as lasting symptoms several weeks after …
substantially to post-COVID-19 syndrome, defined as lasting symptoms several weeks after …
[HTML][HTML] Potent human broadly SARS-CoV-2–neutralizing IgA and IgG antibodies effective against Omicron BA. 1 and BA. 2
C Planchais, I Fernández, T Bruel… - Journal of Experimental …, 2022 - rupress.org
Disclosures: C. Planchais reported a patent to PCT/EP2022/058777 licensed (SpikImm). I.
Fernández reported a patent to PCT/EP2022/058777 licensed (SpikImm). T. Bruel reported …
Fernández reported a patent to PCT/EP2022/058777 licensed (SpikImm). T. Bruel reported …
COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?
WS Ho, R Zhang, YL Tan, CLL Chai - Pharmacological Research, 2022 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic had grounded the world to a
standstill. As the disease continues to rage two years on, it is apparent that effective …
standstill. As the disease continues to rage two years on, it is apparent that effective …
After the virus has cleared—Can preclinical models be employed for Long COVID research?
EB Jansen, SN Orvold, CL Swan, A Yourkowski… - PLoS …, 2022 - journals.plos.org
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) can cause the life-
threatening acute respiratory disease called COVID-19 (Coronavirus Disease 2019) as well …
threatening acute respiratory disease called COVID-19 (Coronavirus Disease 2019) as well …
Niclosamide, but not ivermectin, inhibits anoctamin 1 and 6 and attenuates inflammation of the respiratory tract
J Ousingsawat, R Centeio, R Schreiber… - … -European Journal of …, 2024 - Springer
Inflammatory airway diseases like cystic fibrosis, asthma and COVID-19 are characterized
by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide …
by high levels of pulmonary cytokines. Two well-established antiparasitic drugs, niclosamide …
The SARS-CoV-2 Alpha variant exhibits comparable fitness to the D614G strain in a Syrian hamster model
Abstract Late 2020, SARS-CoV-2 Alpha variant emerged in United Kingdom and gradually
replaced G614 strains initially involved in the global spread of the pandemic. In this study …
replaced G614 strains initially involved in the global spread of the pandemic. In this study …
RNA-dependent RNA polymerase of SARS-CoV-2 regulate host mRNA translation efficiency by hijacking eEF1A factors
H Gan, X Zhou, Q Lei, L Wu, J Niu, Q Zheng - Biochimica et Biophysica Acta …, 2024 - Elsevier
The RNA-dependent RNA polymerase (NSP12) of COVID-19 plays a significant role in the
viral infection process, which promotes viral RNA replication by cooperating with NSP7 and …
viral infection process, which promotes viral RNA replication by cooperating with NSP7 and …