Memories are not written in stone: Re-writing fear memories by means of non-invasive brain stimulation and optogenetic manipulations

S Borgomaneri, S Battaglia, G Sciamanna… - Neuroscience & …, 2021 - Elsevier
The acquisition of fear associative memory requires brain processes of coordinated neural
activity within the amygdala, prefrontal cortex (PFC), hippocampus, thalamus and brainstem …

The advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD research

TCM Bienvenu, C Dejean, D Jercog, B Aouizerate… - Neuron, 2021 - cell.com
Translational research on post-traumatic stress disorder (PTSD) has produced limited
improvements in clinical practice. Fear conditioning (FC) is one of the dominant animal …

Thalamic circuits for independent control of prefrontal signal and noise

A Mukherjee, NH Lam, RD Wimmer, MM Halassa - Nature, 2021 - nature.com
Interactions between the mediodorsal thalamus and the prefrontal cortex are critical for
cognition. Studies in humans indicate that these interactions may resolve uncertainty in …

[HTML][HTML] Intercalated amygdala clusters orchestrate a switch in fear state

KM Hagihara, O Bukalo, M Zeller, A Aksoy-Aksel… - Nature, 2021 - nature.com
Adaptive behaviour necessitates the formation of memories for fearful events, but also that
these memories can be extinguished. Effective extinction prevents excessive and persistent …

Belief traps: Tackling the inertia of harmful beliefs

M Scheffer, D Borsboom… - Proceedings of the …, 2022 - National Acad Sciences
Beliefs can be highly resilient in the sense that they are not easily abandoned in the face of
counterevidence. This has the advantage of guiding consistent behavior and judgments but …

[HTML][HTML] Deconstructing the gestalt: mechanisms of fear, threat, and trauma memory encoding

SA Maddox, J Hartmann, RA Ross, KJ Ressler - Neuron, 2019 - cell.com
Threat processing is central to understanding debilitating fear-and trauma-related disorders
such as posttraumatic stress disorder (PTSD). Progress has been made in understanding …

A thalamic bridge from sensory perception to cognition

M Wolff, S Morceau, R Folkard… - Neuroscience & …, 2021 - Elsevier
The ability to adapt to dynamic environments requires tracking multiple signals with variable
sensory salience and fluctuating behavioral relevance. This complex process requires …

Ginsenoside Rg1 prevents PTSD-like behaviors in mice through promoting synaptic proteins, reducing Kir4. 1 and TNF-α in the hippocampus

Z Zhang, Z Song, F Shen, P Xie, J Wang, A Zhu… - Molecular …, 2021 - Springer
Ginsenoside Rg1 is efficient to prevent or treat mental disorders. However, the mechanisms
underlying the effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD) are still …

COVID-19, isolation, quarantine: on the efficacy of internet-based eye movement desensitization and reprocessing (EMDR) and cognitive-behavioral therapy (CBT) for …

RL Perri, P Castelli, C La Rosa, T Zucchi, A Onofri - Brain Sciences, 2021 - mdpi.com
Literature points to cognitive-behavioural therapy (CBT) and eye movement desensitization
and reprocessing (EMDR) as evidence-based therapies for trauma-related disorders …

EMDR as treatment option for conditions other than PTSD: A systematic review

C Scelles, LC Bulnes - Frontiers in Psychology, 2021 - frontiersin.org
Eye Movement Desensitisation and Reprocessing (EMDR) is a treatment for post-traumatic
stress disorder (PTSD). The technique is known to facilitate reprocessing of maladaptive …