Biomimetic nanoparticle technology for cardiovascular disease detection and treatment

JH Park, D Dehaini, J Zhou, M Holay, RH Fang… - Nanoscale …, 2020 - pubs.rsc.org
Cardiovascular disease (CVD), which encompasses a number of conditions that can affect
the heart and blood vessels, presents a major challenge for modern-day healthcare. Nearly …

A thrombin‐activated peptide‐templated nanozyme for remedying ischemic stroke via thrombolytic and neuroprotective actions

Z Wang, Y Zhao, Y Hou, G Tang, R Zhang… - Advanced …, 2024 - Wiley Online Library
Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …

Tissue plasminogen activator-based nanothrombolysis for ischemic stroke

S Liu, X Feng, R Jin, G Li - Expert opinion on drug delivery, 2018 - Taylor & Francis
Introduction: Thrombolysis with intravenous tissue plasminogen activator (tPA) is the only
FDA approved treatment for patients with acute ischemic stroke, but its use is limited by …

Low-intensity focused ultrasound-responsive phase-transitional nanoparticles for thrombolysis without vascular damage: a synergistic nonpharmaceutical strategy

Y Zhong, Y Zhang, J Xu, J Zhou, J Liu, M Ye, L Zhang… - ACS …, 2019 - ACS Publications
Multimodal molecular imaging has shown promise as a complementary approach to
thrombus detection. However, the simultaneous noninvasive detection and lysis of thrombi …

Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment–synergistic effect of thrombolysis …

T Mei, A Kim, LB Vong, A Marushima, S Puentes… - Biomaterials, 2019 - Elsevier
The medical treatment for stroke has advanced greatly in recent years. Thrombolytic therapy
with tissue plasminogen activator (t-PA) is one of the mainstream treatments, but it still has …

Synthesis and applications of Fe3O4/SiO2 core-shell materials

M Sonmez, M Georgescu… - Current …, 2015 - ingentaconnect.com
Multifunctional nanoparticles based on magnetite/silica core-shell, consisting of iron oxides
coated with silica matrix doped with fluorescent components such as organic dyes …

Preclinical evaluation and clinical translation of magnetite-based nanomedicines

JV Nuzhina, AA Shtil, AY Prilepskii… - Journal of Drug Delivery …, 2019 - Elsevier
Over the last decade, magnetic iron oxide nanoparticles have attracted considerable interest
in the field of nanomedicine due to their unique magnetic properties, biocompatibility, and …

The promising shadow of microbubble over medical sciences: from fighting wide scope of prevalence disease to cancer eradication

A Jangjou, AH Meisami, K Jamali, MH Niakan… - Journal of Biomedical …, 2021 - Springer
Abstract Microbubbles are typically 0.5–10 μm in size. Their size tends to make it easier for
medication delivery mechanisms to navigate the body by allowing them to be swallowed …

[HTML][HTML] Particles in coronary circulation: A review on modelling for drug carrier design

M Forouzandehmehr, I Ghoytasi, A Shamloo, S Ghosi - Materials & Design, 2022 - Elsevier
Atherosclerotic plaques and thrombosis are chronic inflammatory complications and the
main manifestations of cardiovascular diseases (CVD), the leading cause of death globally …

Multimodal and multifunctional nanoparticles with platelet targeting ability and phase transition efficiency for the molecular imaging and thrombolysis of coronary …

S Bai, J Liao, B Zhang, M Zhao, B You, P Li… - Biomaterials …, 2020 - pubs.rsc.org
Recently, coronary microthrombosis has received attention owing to its involvement in the
pathophysiological process of no-reflow after acute myocardial ischemia/reperfusion. Due to …