Maturity-onset diabetes of the young (MODY) is characterized by autosomal dominant
inheritance, onset before 25 years of age, absence of β-cell autoimmunity, and sustained …

Maturity-onset diabetes of the young (MODY) is an unusual form of diabetes with specific
features that distinguish it from type 1 and type 2 diabetes. There are 14 known subtypes of …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive or non-Mendelian trait or may present as a …

ISPAD Clinical Practice Consensus Guidelines 2022: The diagnosis and management of
monogenic diabetes in children and adolescents - PMC Back to Top Skip to main content NIH …

Glucokinase–maturity-onset diabetes of the young (GCK-MODY), also known as MODY2, is
caused by heterozygous inactivating mutations in the GCK gene. GCK gene mutations are …

Importance Glycemic targets in diabetes have been developed to minimize complication
risk. Patients with heterozygous, inactivating glucokinase (GCK) mutations have mild fasting …

Maturity-onset diabetes of the young (MODY) is a group of monogenic disorders
characterized by autosomal dominantly inherited non-insulin dependent form of diabetes …

Glucokinase is a key regulatory enzyme in the pancreatic beta‐cell. It plays a crucial role in
the regulation of insulin secretion and has been termed the glucose sensor in pancreatic …

Aims/hypothesis Diagnosing MODY is difficult. To date, selection for molecular genetic
testing for MODY has used discrete cut-offs of limited clinical characteristics with varying …

Monogenic diabetes resulting from mutations that primarily reduce β-cell function accounts
for 1–2% of diabetes cases, although it is often misdiagnosed as either type 1 or type 2 …