Ten decadal advances in fungal biology leading towards human well-being

A Mapook, KD Hyde, K Hassan, BM Kemkuignou… - Fungal Diversity, 2022 - Springer
Fungi are an understudied resource possessing huge potential for developing products that
can greatly improve human well-being. In the current paper, we highlight some important …

Developing Aspergillus niger as a cell factory for food enzyme production

C Li, J Zhou, G Du, J Chen, S Takahashi, S Liu - Biotechnology Advances, 2020 - Elsevier
Aspergillus niger has become one of the most important hosts for food enzyme production
due to its unique food safety characteristics and excellent protein secretion systems. A series …

Employment of the CRISPR/Cas9 system to improve cellulase production in Trichoderma reesei

S Pant, P Nag, A Ghati, D Chakraborty… - Biotechnology …, 2022 - Elsevier
Trichoderma reesei has been explored intensively in the laboratory and on an industrial
scale for its highly potent cellulase secretion machinery since its characterization over 70 …

Transcriptional activation of biosynthetic gene clusters in filamentous fungi

L Mózsik, R Iacovelli, RAL Bovenberg… - … in Bioengineering and …, 2022 - frontiersin.org
Filamentous fungi are highly productive cell factories, many of which are industrial
producers of enzymes, organic acids, and secondary metabolites. The increasing number of …

Development and application of CRISPR/Cas in microbial biotechnology

W Ding, Y Zhang, S Shi - Frontiers in Bioengineering and …, 2020 - frontiersin.org
The clustered regularly interspaced short palindromic repeats (CRISPR)-associated (Cas)
system has been rapidly developed as versatile genomic engineering tools with high …

The CRISPR toolbox in medical mycology: State of the art and perspectives

F Morio, L Lombardi, G Butler - PLoS pathogens, 2020 - journals.plos.org
Fungal pathogens represent a major human threat affecting more than a billion people
worldwide. Invasive infections are on the rise, which is of considerable concern because …

Advances and challenges in CRISPR/Cas-based fungal genome engineering for secondary metabolite production: a review

D Wang, S Jin, Q Lu, Y Chen - Journal of Fungi, 2023 - mdpi.com
Fungi represent an important source of bioactive secondary metabolites (SMs), which have
wide applications in many fields, including medicine, agriculture, human health, and many …

Use of CRISPR‐Cas tools to engineer Trichoderma species

Y Wang, H Chen, L Ma, M Gong, Y Wu… - Microbial …, 2022 - Wiley Online Library
Given their lignocellulose degradability and biocontrol activities, fungi of the ubiquitously
distributed genus Trichoderma have multiple industrial and agricultural applications. Genetic …

Post-translational modifications drive success and failure of fungal–host interactions

C Retanal, B Ball, J Geddes-McAlister - Journal of Fungi, 2021 - mdpi.com
Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …

How to completely squeeze a fungus—advanced genome mining tools for novel bioactive substances

A Schüller, L Studt-Reinhold, J Strauss - Pharmaceutics, 2022 - mdpi.com
Fungal species have the capability of producing an overwhelming diversity of bioactive
substances that can have beneficial but also detrimental effects on human health. These so …