Parkinson's disease (PD) is an adult onset neurodegenerative disease that is characterized
by selective degeneration of neurons primarily in the substantia nigra. At present, the …

Allometric scaling of metabolic rate results in lower total mitochondrial oxygen consumption
with increasing organismal size. This is considered a universal law in biology. Here, we …

Mitochondrial dysfunction is at the core of many diseases ranging from inherited metabolic
diseases to common conditions that are associated with aging. Although associations …

Growing evidence indicates that gut microbiota play a critical role in regulating the
progression of neurodegenerative diseases such as Parkinson's disease. The molecular …

The oxidative environment within the mitochondria makes them particularly vulnerable to
proteotoxic stress. To maintain a healthy mitochondrial network, eukaryotes have evolved …

Mitochondria are essential components of eukaryotic cells, carrying out critical physiological
processes that include energy production and calcium buffering. Consequently …

While the pathogenesis of Parkinson's disease (PD) is incompletely understood,
mitochondrial dysfunction is thought to play a crucial role in disease pathogenesis. Here, we …

Mitochondrial functions are essential for life, critical for development, maintenance of stem
cells, adaptation to physiological changes, responses to stress, and aging. The complexity of …

Immunological mediators that originate outside the nervous system can affect neuronal
health. However, their roles in neurodegeneration remain largely unknown. Here, we show …

Acute heat stress (aHS) can induce strong developmental defects in Caenorhabditis
elegans larva but not lethality or sterility. This stress results in transitory fragmentation of …