[HTML][HTML] Fascin actin-bundling protein 1 in human cancer: promising biomarker or therapeutic target?
H Liu, Y Zhang, L Li, J Cao, Y Guo, Y Wu… - Molecular Therapy …, 2021 - cell.com
Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …
[HTML][HTML] FSCN1 acts as a promising therapeutic target in the blockade of tumor cell motility: a review of its function, mechanism, and clinical significance
Z Li, J Shi, N Zhang, X Zheng, Y Jin, S Wen… - Journal of …, 2022 - ncbi.nlm.nih.gov
Fascin actin-bundling protein 1 (FSCN1) is an actin-bundling protein that is capable of
inducing membrane protrusions and plays critical roles in cell migration, motility, adhesion …
inducing membrane protrusions and plays critical roles in cell migration, motility, adhesion …
[HTML][HTML] Fascin enhances the vulnerability of breast cancer to erastin-induced ferroptosis
C Chen, B Xie, Z Li, L Chen, Y Chen, J Zhou, S Ju… - Cell death & …, 2022 - nature.com
Ferroptosis, which is characterized by intracellular iron accumulation and lipid peroxidation,
is a newly described form of regulated cell death that may play a key role in tumour …
is a newly described form of regulated cell death that may play a key role in tumour …
[HTML][HTML] SOX2 promotes brain metastasis of breast cancer by upregulating the expression of FSCN1 and HBEGF
W Xiao, S Zheng, X Xie, X Li, L Zhang, A Yang… - Molecular Therapy …, 2020 - cell.com
The prognosis of breast cancer brain metastasis (BCBM) is extremely poor due to its
resistance to conventional therapy. Elucidation of the molecular mechanisms of BCBM could …
resistance to conventional therapy. Elucidation of the molecular mechanisms of BCBM could …
[HTML][HTML] GRHL3 activates FSCN1 to relax cell-cell adhesions between migrating keratinocytes during wound reepithelialization
G Kashgari, S Venkatesh, S Refuerzo, B Pham… - JCI insight, 2021 - ncbi.nlm.nih.gov
The migrating keratinocyte wound front is required for skin wound closure. Despite
significant advances in wound healing research, we do not fully understand the molecular …
significant advances in wound healing research, we do not fully understand the molecular …
[HTML][HTML] PRNCR1: a long non-coding RNA with a pivotal oncogenic role in cancer
Long non-coding RNAs (lncRNAs) have been gaining importance in the field of cancer
research in recent years. PRNCR1 (prostate cancer-associated non-coding RNA1) is a 12.7 …
research in recent years. PRNCR1 (prostate cancer-associated non-coding RNA1) is a 12.7 …
[HTML][HTML] LncRNA LOC146880 promotes esophageal squamous cell carcinoma progression via miR-328-5p/FSCN1/MAPK axis
J Tang, H Xu, Q Liu, J Zheng, C Pan, Z Li… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
We investigated the role of long non-coding RNA (lncRNA) LOC146880 in esophageal
squamous cell carcinoma (ESCC). LOC146880 was significantly upregulated in ESCC …
squamous cell carcinoma (ESCC). LOC146880 was significantly upregulated in ESCC …
LncRNA CRNDE promotes cell proliferation, migration and invasion of ovarian cancer via miR-423-5p/FSCN1 axis
Q Wang, LX Wang, CY Zhang, N Bai, C Feng… - Molecular and Cellular …, 2022 - Springer
Ovarian cancer seriously threatens the health of women. LncRNA CRNDE is known to be
upregulated in ovarian cancer. However, the mechanism by which CRNDE regulates the …
upregulated in ovarian cancer. However, the mechanism by which CRNDE regulates the …
[HTML][HTML] Loss of MEG3 contributes to the enhanced migration and invasion in arsenic-induced carcinogenesis through NQO1/FSCN1 pathway
Arsenic ranks at the top among all toxic metals and poses a serious threat to human health.
Inorganic arsenite and arsenate compounds have been classified as human carcinogens in …
Inorganic arsenite and arsenate compounds have been classified as human carcinogens in …
FSCN1 induced PTPRF-dependent tumor microenvironment inflammatory reprogramming promotes lung adenocarcinoma progression via regulating macrophagic …
Y Huang, G Shan, Y Yi, J Liang, Z Hu, G Bi, Z Chen… - Cellular Oncology, 2022 - Springer
Abstract Purpose Macrophages (MΦs) play a dual role in the promotion and suppression of
lung adenocarcinoma (LUAD), the function of which is influenced by the metabolic status …
lung adenocarcinoma (LUAD), the function of which is influenced by the metabolic status …