Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches

AR Schwartz, SP Patil, AM Laffan… - Proceedings of the …, 2008 - atsjournals.org
Obstructive sleep apnea is a common disorder whose prevalence is linked to an epidemic of
obesity in Western society. Sleep apnea is due to recurrent episodes of upper airway …

Obesity and obstructive sleep apnea

AS Gami, SM Caples, VK Somers - … and Metabolism Clinics, 2003 - endo.theclinics.com
Obesity is the most powerful risk factor for obstructive sleep apnea (OSA), and it is
essentially the only reversible one. OSA and obesity share common substrates, pathologic …

Effect of weight loss on upper airway collapsibility in obstructive sleep apnea1-3

AR Schwartz, AR Gold, N Schubert, A Stryzak - Am Rev Respir Dis, 1991 - atsjournals.org
Previous investigators have demonstrated in patients with obstructive sleep apnea that
weight reduction results in a decrease in apnea severity. Although the mechanism for this …

Sleep apnea and sleep disruption in obese patients

AN Vgontzas, TL Tan, EO Bixler… - Archives of internal …, 1994 - jamanetwork.com
Objectives: To describe the frequency and severity of sleep apnea in obese patients without
a primary sleep complaint and to assess the sleep patterns of obese patients without apnea …

Weight loss in mildly to moderately obese patients with obstructive sleep apnea

PL Smith, AR GOLD, DA MEYERS… - Annals of internal …, 1985 - acpjournals.org
Excerpt The therapeutic effects of weight loss were evaluated in 15 hypersomnolent patients
with moderately severe obstructive sleep apnea. As patients decreased their body weight …

Surgery and obstructive sleep apnea: long-term clinical outcomes

RW Riley, NB Powell, KK Li, RJ Troell… - … —Head and Neck …, 2000 - journals.sagepub.com
OBJECTIVE Outcome data on the surgical treatment of obstructive sleep apnea are, in
general, based on short-term follow-up (< 6–9 months). This examination was undertaken to …

Effect of anterior mandibular positioning on obstructive sleep apnea

GT Clark, D Arand, E Chung, D Tong - American Review of …, 1993 - atsjournals.org
This prospective case report series utilized an anterior mandibular positioning (AMP) device
on obstructive sleep apnea (OSA) patients and evaluated the changes in the respiratory …

Expression of leptin receptor in lung: leptin as a growth factor

T Tsuchiya, H Shimizu, T Horie, M Mori - European journal of pharmacology, 1999 - Elsevier
Leptin receptors are expressed in various tissues in rodents but their function is not clear.
The present studies were undertaken to investigate the function of the leptin receptor in …

Long-term results of maxillomandibular advancement surgery

KK Li, NB Powell, RW Riley, RJ Troell… - Sleep and …, 2000 - thieme-connect.com
Surgery is a major modality in the treatment of obstructive sleep apnea syndrome (OSAS),
and maxillomandibular advancement (MMA) has been shown to be the most effective …

[引用][C] Sites and sizes of fat deposits around the pharynx in obese patients with obstructive sleep apnoea and weight matched controls

RL Horner, RH Mohiaddin, DG Lowell… - European …, 1989 - Eur Respiratory Soc