Chemical Biology of H2S Signaling through Persulfidation

MR Filipovic, J Zivanovic, B Alvarez… - Chemical …, 2018 - ACS Publications
Signaling by H2S is proposed to occur via persulfidation, a posttranslational modification of
cysteine residues (RSH) to persulfides (RSSH). Persulfidation provides a framework for …

Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways

TV Mishanina, M Libiad, R Banerjee - Nature chemical biology, 2015 - nature.com
The chemical species involved in H2S signaling remain elusive despite the profound and
pleiotropic physiological effects elicited by this molecule. The dominant candidate …

Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility

K Ono, T Akaike, T Sawa, Y Kumagai, DA Wink… - Free Radical Biology …, 2014 - Elsevier
Hydrogen sulfide (H 2 S) is an endogenously generated and putative signaling/effector
molecule. Despite its numerous reported functions, the chemistry by which it elicits its …

C–H⋯ S hydrogen bonding interactions

HA Fargher, TJ Sherbow, MM Haley… - Chemical Society …, 2022 - pubs.rsc.org
The short C–H⋯ S contacts found in available structural data for both small molecules and
larger biomolecular systems suggest that such contacts are an often overlooked yet …

Redox biochemistry of hydrogen sulfide

O Kabil, R Banerjee - Journal of Biological Chemistry, 2010 - ASBMB
H 2 S, the most recently discovered gasotransmitter, might in fact be the evolutionary
matriarch of this family, being both ancient and highly reduced. Disruption of γ-cystathionase …

[HTML][HTML] Chemical foundations of hydrogen sulfide biology

Q Li, JR Lancaster Jr - Nitric oxide, 2013 - Elsevier
Following nitric oxide (nitrogen monoxide) and carbon monoxide, hydrogen sulfide (or its
newer systematic name sulfane, H 2 S) became the third small molecule that can be both …

Hydrogen sulfide: an emerging precision strategy for gas therapy

H Ding, J Chang, F He, S Gai… - Advanced Healthcare …, 2022 - Wiley Online Library
Advances in nanotechnology have enabled the rapid development of stimuli‐responsive
therapeutic nanomaterials for precision gas therapy. Hydrogen sulfide (H2S) is a significant …

Measurement of plasma hydrogen sulfide in vivo and in vitro

X Shen, CB Pattillo, S Pardue, SC Bir, R Wang… - Free Radical Biology …, 2011 - Elsevier
The gasotransmitter hydrogen sulfide is known to regulate multiple cellular functions during
normal and pathophysiological states. However, a paucity of concise information exists …

H2S and its role in redox signaling

O Kabil, N Motl, R Banerjee - Biochimica et Biophysica Acta (BBA)-Proteins …, 2014 - Elsevier
Hydrogen sulfide (H 2 S) has emerged as an important gaseous signaling molecule that is
produced endogenously by enzymes in the sulfur metabolic network. H 2 S exerts its effects …

Persulfidation (S-sulfhydration) and H2S

MR Filipovic - … , biochemistry and pharmacology of hydrogen sulfide, 2015 - Springer
The past decade has witnessed the discovery of hydrogen sulfide (H 2 S) as a new
signalling molecule. Its ability to act as a neurotransmitter, regulator of blood pressure …