Auditory neuropathy—neural and synaptic mechanisms

T Moser, A Starr - Nature Reviews Neurology, 2016 - nature.com
Sensorineural hearing impairment is the most common form of hearing loss, and
encompasses pathologies of the cochlea and the auditory nerve. Hearing impairment …

Otoferlin: a multi-C2 domain protein essential for hearing

T Pangršič, E Reisinger, T Moser - Trends in neurosciences, 2012 - cell.com
Sound is encoded at synapses between cochlear inner hair cells and the auditory nerve.
These synapses are anatomically and functionally specialized to transmit acoustic …

Toward a differential diagnosis of hidden hearing loss in humans

MC Liberman, MJ Epstein, SS Cleveland, H Wang… - PloS one, 2016 - journals.plos.org
Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …

Synaptopathy in the noise-exposed and aging cochlea: Primary neural degeneration in acquired sensorineural hearing loss

SG Kujawa, MC Liberman - Hearing research, 2015 - Elsevier
The classic view of sensorineural hearing loss (SNHL) is that the “primary” targets are hair
cells, and that cochlear-nerve loss is “secondary” to hair cell degeneration. Our recent work …

Age-related cochlear synaptopathy: an early-onset contributor to auditory functional decline

Y Sergeyenko, K Lall, MC Liberman… - Journal of …, 2013 - Soc Neuroscience
Aging listeners experience greater difficulty understanding speech in adverse listening
conditions and exhibit degraded temporal resolution, even when audiometric thresholds are …

Middle ear muscle reflex and word recognition in “normal-hearing” adults: evidence for cochlear synaptopathy?

AM Mepani, SA Kirk, KE Hancock, K Bennett… - Ear and …, 2020 - journals.lww.com
Objectives: Permanent threshold elevation after noise exposure, ototoxic drugs, or aging is
caused by loss of sensory cells; however, animal studies show that hair cell loss is often …

Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects

KJ Grant, AM Mepani, P Wu… - Journal of …, 2020 - journals.physiology.org
Hearing loss caused by noise exposure, ototoxic drugs, or aging results from the loss of
sensory cells, as reflected in audiometric threshold elevation. Animal studies show that loss …

Morris Halle: an appreciation

M Liberman - Annual Review of Linguistics, 2016 - annualreviews.org
Morris Halle has been one of the most influential figures in modern linguistics. This is partly
due to his scientific contributions in many areas: insights into the sound patterns of English …

The natural history, clinical outcomes, and genotype–phenotype relationship of otoferlin-related hearing loss: a systematic, quantitative literature review

CL Ford, WJ Riggs, T Quigley, OP Keifer Jr, JP Whitton… - Human Genetics, 2023 - Springer
Congenital hearing loss affects one in 500 newborns. Sequence variations in OTOF, which
encodes the calcium-binding protein otoferlin, are responsible for 1–8% of congenital …

[HTML][HTML] Use of the auditory brainstem response for assessment of cochlear synaptopathy in humans

NF Bramhall - The Journal of the Acoustical Society of America, 2021 - pubs.aip.org
Although clinical use of the auditory brainstem response (ABR) to detect retrocochlear
disorders has been largely replaced by imaging in recent years, the discovery of cochlear …