The vertebrate nervous system exhibits dramatic variability in regenerative capacity across
species and neuronal populations. For example, while the mammalian central nervous …

Damage to the central nervous system (CNS) of fish can often be repaired to restore
function, but in mammals recovery from CNS injuries usually fails due to a lack of axon …

A central and long-standing tenet in the conceptualization of animal swimming is the idea
that propulsive thrust is generated by pushing the surrounding water rearward. Inherent in …

Spinal injuries in many vertebrates can result in partial or complete loss of locomotor ability.
While mammals often experience permanent loss, some nonmammals, such as lampreys …

In mammals, spinal cord injury (SCI) leads to dramatic losses in neurons and synaptic
connections, and consequently function. Unlike mammals, lampreys are vertebrates that …

Parkinson's disease is associated with multiplication of the α-synuclein gene and abnormal
accumulation of the protein. In animal models, α-synuclein overexpression broadly impairs …

Spinal cord injury is a devastating condition in which massive cell death and disruption of
neural circuitry lead to long-term chronic functional impairment and paralysis. In mammals …

Locomotion is an essential behaviour for the survival of all animals. The neural circuitry
underlying locomotion is therefore highly robust to a wide variety of perturbations, including …

Mitochondria are highly dynamic organelles that can exhibit a wide range of morphologies.
Mitochondrial morphology can differ significantly across cell types, reflecting different …

Regeneration requires cellular proliferation, differentiation, and other processes that are
regulated by secreted cues originating from cells in the local environment. Recent studies …