Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter

JL Wallace, R Wang - Nature reviews Drug discovery, 2015 - nature.com
Hydrogen sulfide (H2S) has become recognized as an important signalling molecule
throughout the body, contributing to many physiological and pathological processes. In …

Physiological implications of hydrogen sulfide: a whiff exploration that blossomed

R Wang - Physiological reviews, 2012 - journals.physiology.org
The important life-supporting role of hydrogen sulfide (H2S) has evolved from bacteria to
plants, invertebrates, vertebrates, and finally to mammals. Over the centuries, however, H2S …

Cystathionine-β-synthase: molecular regulation and pharmacological inhibition

K Zuhra, F Augsburger, T Majtan, C Szabo - Biomolecules, 2020 - mdpi.com
Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Progress and perspective on hydrogen sulfide donors and their biomedical applications

ZL Song, L Zhao, T Ma, A Osama… - Medicinal Research …, 2022 - Wiley Online Library
Following the discovery of nitric oxide (NO) and carbon monoxide (CO), hydrogen sulfide
(H2S) has been identified as the third gasotransmitter in humans. Increasing evidence have …

Sulfur amino acid metabolism: pathways for production and removal of homocysteine and cysteine

MH Stipanuk - Annu. Rev. Nutr., 2004 - annualreviews.org
▪ Abstract Tissue concentrations of both homocysteine (Hcy) and cysteine (Cys) are
maintained at low levels by regulated production and efficient removal of these thiols. The …

Hydrogen sulfide and cellular redox homeostasis

ZZ Xie, Y Liu, JS Bian - Oxidative medicine and cellular …, 2016 - Wiley Online Library
Intracellular redox imbalance is mainly caused by overproduction of reactive oxygen species
(ROS) or weakness of the natural antioxidant defense system. It is involved in the …

Emerging role of hydrogen sulfide in health and disease: critical appraisal of biomarkers and pharmacological tools

M Whiteman, S Le Trionnaire, M Chopra, B Fox… - Clinical …, 2011 - portlandpress.com
H2S (hydrogen sulfide) is a well known and pungent gas recently discovered to be
synthesized enzymatically in mammalian and human tissues. In a relatively short period of …

Measurement of plasma hydrogen sulfide in vivo and in vitro

X Shen, CB Pattillo, S Pardue, SC Bir, R Wang… - Free Radical Biology …, 2011 - Elsevier
The gasotransmitter hydrogen sulfide is known to regulate multiple cellular functions during
normal and pathophysiological states. However, a paucity of concise information exists …

[HTML][HTML] Surface-fill H2S-releasing silk fibroin hydrogel for brain repair through the repression of neuronal pyroptosis

X Chen, X Huang, C Liu, S Li, Z Yang, F Zhang… - Acta Biomaterialia, 2022 - Elsevier
Traumatic brain injury (TBI) remains the major cause of disability and mortality worldwide
due to the persistent neuroinflammation and neuronal death induced by TBI. Among them …