Abstract Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative
disorder characterised by the progressive loss of motor neurons in the brain and spinal cord …

Objectives The lack of systematic evidence on neuroimaging findings in motor neuron
diseases (MND) hampers the diagnostic utility of magnetic resonance imaging (MRI). Thus …

The notion that the cerebellum is devoted exclusively to motor control has been replaced by
a more sophisticated understanding of its role in neurological function, one that includes …

Amyotrophic lateral sclerosis is a relentlessly progressive multi-system condition. The
clinical picture is dominated by upper and lower motor neuron degeneration, but extra-motor …

Conclusions To date, the research on humoral, radiological, neurophysiological, and
genetic correlates of neuropsychological alterations is at the early stage, and no conclusive …

Objective Cognitive impairment is a common, far-reaching but imperceptible manifestation in
patients with amyotrophic lateral sclerosis (ALS). We aimed to identify the risk factors for …

While C9orf72-specific imaging signatures have been proposed by both ALS and FTD
research groups and considerable presymptomatic alterations have also been confirmed in …

Background Spinal muscular atrophy (SMA) is a genetic motor neuron disease related to
deletions in the SMN1 gene. There is mounting evidence that the disease is not restricted to …

Objective To investigate cognitive inhibition in presymptomatic C9orf72 mutation carriers
(C9+) and its associated neuroanatomical correlates. Methods Thirty-eight presymptomatic …

Neurodegenerative diseases (NDs) are a group of neurological disorders characterized by
the progressive dysfunction of neurons and glial cells, leading to their structural and …