The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

The epithelial-mesenchymal transition (EMT) is required in the embryo for the formation of
tissues for which cells originate far from their final destination. Carcinoma cells hijack this …

Cellular heterogeneity represents one of the greatest challenges in cancer therapeutics. In
many malignancies, this heterogeneity is generated during tumor evolution through a …

Cancer cells within individual tumors often exist in distinct phenotypic states that differ in
functional attributes. While cancer cell populations typically display distinctive equilibria in …

The mammary epithelium undergoes profound morphogenetic changes during
development. Architecturally, it comprises two primary lineages, the inner luminal and outer …

The mammary epithelium is composed of several cell lineages including luminal, alveolar
and myoepithelial cells. Transplantation studies have suggested that the mammary …

The epithelial-mesenchymal transition (EMT) is a key developmental program that is often
activated during cancer invasion and metastasis. We here report that the induction of an …

Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such,
heterogeneity is one of the most important and clinically relevant areas of cancer research …

The adult mouse mammary epithelium contains self-sustained cell lineages that form the
inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its …