Ceulemans, Hugo, and Mathieu Bollen. Functional Diversity of Protein Phosphatase-1, a
Cellular Economizer and Reset Button. Physiol Rev 84: 1–39, 2004; 10.1152/physrev …

The catalytic subunit of the type 1 Ser/Thr protein phosphatases (PP1) can interact with
many different regulatory (R) subunits. These R subunits function as activity-modulators …

Abstract Protein phosphatase 2A (PP2A) is a principal Ser/Thr phosphatase, the
deregulation of which is associated with multiple human cancers, Alzheimer's disease and …

The coordinated and reciprocal action of serine/threonine (Ser/Thr) protein kinases and
phosphatases produces transient phosphorylation, a fundamental regulatory mechanism for …

The growth arrest and DNA damage-inducible protein, GADD34, was identified by its
interaction with human inhibitor 1 (I-1), a protein kinase A (PKA)-activated inhibitor of type 1 …

Most interactors of protein phosphatase-1 (PP1) contain a variant of a so-called" RVXF"
sequence that binds to a hydrophobic groove of the catalytic subunit. A combination of …

Despite advances in understanding the role of histone deacetylases (HDACs) in
tumorigenesis, the mechanism by which HDAC inhibitors mediate antineoplastic effects …

Protein phosphatase-1 (PP1) plays a key role in dephosphorylation in numerous biological
processes such as glycogen metabolism, cell cycle regulation, smooth muscle contraction …

A review of the current status of the chemistry and biology of fostriecin (CI-920) is provided.
Fostriecin is a structurally unique, naturally-occurring phosphate monoester that exhibits …

BAD is a proapoptotic member of the BCL-2 family of proteins, which play a major role in
regulating apoptosis in cytokine-dependent hematopoietic cells. The function of BAD is …