A review and perspective paper: Ras oncogene gets modest, from kingpin to mere henchman
JH Camonis, VN Aushev, E Zueva… - Cellular and Molecular Life …, 2024 - Springer
The concomitant activation of both the YAP1 co-transcription factor and RAS GTPases is a
hallmark of several aggressive cancers, though the intricacies of their relationship and …
hallmark of several aggressive cancers, though the intricacies of their relationship and …
Novel Targets and Advanced Therapies in Diffuse Large B Cell Lymphomas
F D'Alò, S Bellesi, E Maiolo, E Alma, F Bellisario… - Cancers, 2024 - mdpi.com
Simple Summary Diffuse large B cell lymphoma is the most common type of B cell
neoplasm, and can be cured by traditional chemoimmunotherapy in 60–70% of cases …
neoplasm, and can be cured by traditional chemoimmunotherapy in 60–70% of cases …
Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma
A Deutzmann, DK Sullivan, R Dhanasekaran… - Nature …, 2024 - nature.com
The MYC oncogene is often dysregulated in human cancer, including hepatocellular
carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively …
carcinoma (HCC). MYC is considered undruggable to date. Here, we comprehensively …
XPO1-mediated mRNA export of genome maintenance regulators drives chemotherapy resistance in aggressive lymphoma
G Knittel, HC Reinhardt - Cancer Research, 2024 - AACR
Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoid malignancy and
displays vast genetic and transcriptomic heterogeneity. Current treatment guidelines …
displays vast genetic and transcriptomic heterogeneity. Current treatment guidelines …
NSUN4-mediated m5C modification of circERI3 promotes lung cancer development by altering mitochondrial energy metabolism
J Wu, Q Zhao, S Chen, H Xu, R Zhang, D Cai, Y Gao… - Cancer Letters, 2024 - Elsevier
As a highly important methylation modification, the 5-methyladenosine (m5C) modification
can profoundly affect RNAs by regulating their transcription, structure and stability. With the …
can profoundly affect RNAs by regulating their transcription, structure and stability. With the …
Lurbinectedin sensitizes PD-L1 blockade therapy by activating STING-IFN signaling in small-cell lung cancer
Lurbinectedin is an approved second-line treatment for small-cell lung cancer (SCLC).
SCLC clinical trials combining lurbinectedin with PD-L1 blockade are currently ongoing …
SCLC clinical trials combining lurbinectedin with PD-L1 blockade are currently ongoing …
[HTML][HTML] Germinal Center Dark Zone harbors ATR-dependent determinants of T-cell exclusion that are also identified in aggressive lymphoma
The germinal center (GC) dark zone (DZ) and light zone (LZ) regions spatially separate
expansion and diversification from selection of antigen-specific B-cells to ensure antibody …
expansion and diversification from selection of antigen-specific B-cells to ensure antibody …
The GATA-3 dependent transcriptome and tumor microenvironment are regulated by eIF4E and XPO1 in T-cell lymphomas
N Kady, S Abdelrahman, AM Rauf, A Burgess, J Weiss… - Blood, 2024 - Elsevier
The transcription factor GATA-3 and the transcriptional program it regulates have emerged
as oncogenic drivers across diverse T-cell lymphomas (TCL), many of which are resistant to …
as oncogenic drivers across diverse T-cell lymphomas (TCL), many of which are resistant to …