Giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) are two interrelated
inflammatory diseases affecting patients above 50 years of age. Patients with GCA suffer …

The giant cell arteritis (GCA) pathophysiology is complex and multifactorial, involving a
predisposing genetic background, the role of immune aging and the activation of vascular …

Objective To identify the key coding genes underlying the biomarkers and pathways
associated with giant cell arteritis (GCA), we performed an in situ spatial profiling of …

Vasculitis is an autoimmune vascular inflammation with an unknown etiology and causes
vessel wall destruction. Depending on the size of the blood vessels, it is classified as large …

Non-invasive imaging modalities constitute an increasingly important tool in diagnostic and
therapy response monitoring of patients with autoimmune diseases, including rheumatoid …

Large-vessel vasculitis (LVV) are autoimmune and autoinflammatory diseases focused on
vascular inflammation. The central core of the intricate immunological and molecular …

Objective The lack of disease-specific autoantibodies in giant cell arteritis (GCA) suggests
an alternative role for B-cells readily detected in the inflamed arteries. Here we study the …

Giant cell arteritis (GCA) is a noninfectious granulomatous vasculitis of unknown etiology
affecting individuals older than 50 years. Two forms of GCA have been identified: a cranial …

Vascular smooth muscle cells (VSMCs) have been shown to play a role in the pathogenesis
of giant cell arteritis (GCA) through their capacity to produce chemokines recruiting T cells …

β2 integrins are transmembrane receptors that exist widely in human immune cells and
participate in pathological processes such as chronic inflammation, thrombosis, and …