NADPH oxidases (NOX): an overview from discovery, molecular mechanisms to physiology and pathology
The reactive oxygen species (ROS)-producing enzyme NADPH oxidase (NOX) was first
identified in the membrane of phagocytic cells. For many years, its only known role was in …
identified in the membrane of phagocytic cells. For many years, its only known role was in …
COVID-19, renin-angiotensin system and endothelial dysfunction
R Amraei, N Rahimi - Cells, 2020 - mdpi.com
The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused
by SARS-CoV-2 virus, has posed a serious threat to global public health and caused …
by SARS-CoV-2 virus, has posed a serious threat to global public health and caused …
Calcium signaling mechanisms across kingdoms
Calcium (Ca2+) is a unique mineral that serves as both a nutrient and a signal in all
eukaryotes. To maintain Ca2+ homeostasis for both nutrition and signaling purposes, the …
eukaryotes. To maintain Ca2+ homeostasis for both nutrition and signaling purposes, the …
Genetically encoded fluorescent biosensors illuminate the spatiotemporal regulation of signaling networks
EC Greenwald, S Mehta, J Zhang - Chemical reviews, 2018 - ACS Publications
Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …
The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas
OH Petersen, JV Gerasimenko… - Physiological …, 2021 - journals.physiology.org
This review deals with the roles of calcium ions and ATP in the control of the normal
functions of the different cell types in the exocrine pancreas as well as the roles of these …
functions of the different cell types in the exocrine pancreas as well as the roles of these …
[HTML][HTML] Smooth muscle ion channels and regulation of vascular tone in resistance arteries and arterioles
NR Tykocki, EM Boerman… - Comprehensive Physiology, 2017 - ncbi.nlm.nih.gov
Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …
Neuronal calcium signaling: function and dysfunction
Abstract Calcium (Ca 2+) is an universal second messenger that regulates the most
important activities of all eukaryotic cells. It is of critical importance to neurons as it …
important activities of all eukaryotic cells. It is of critical importance to neurons as it …
GAP-43 and BASP1 in axon regeneration: implications for the treatment of neurodegenerative diseases
D Chung, A Shum, G Caraveo - Frontiers in cell and developmental …, 2020 - frontiersin.org
Growth-associated protein-43 (GAP-43) and brain acid-soluble protein 1 (BASP1) regulate
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …
actin dynamics and presynaptic vesicle cycling at axon terminals, thereby facilitating axonal …
Phospholipase A2 Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
earliest enzyme activities to be identified and studied, and the phospholipase A2 (PLA2) …
Fusion tags for protein solubility, purification and immunogenicity in Escherichia coli: the novel Fh8 system
Proteins are now widely produced in diverse microbial cell factories. The Escherichia coli is
still the dominant host for recombinant protein production but, as a bacterial cell, it also has …
still the dominant host for recombinant protein production but, as a bacterial cell, it also has …