Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

Introduction In the last 10 years the field of mitochondrial genetics has widened, shifting the
focus from rare sporadic, metabolic disease to the effects of mitochondrial DNA (mtDNA) …

Since the earliest descriptions of Alzheimer's disease (AD), many theories have been
advanced as to its cause. These include:(1) exacerbation of aging,(2) degeneration of …

Mitochondrial dysfunction is observed in both the aging brain, and as a core feature of
several neurodegenerative diseases. A central mechanism mediating this dysfunction is …

Objective The inherited component for Alzheimer disease (AD) risk has focused on close
relatives; consideration of the full family history may improve accuracy and utility of risk …

Alzheimer's disease is the most common form of dementia and is the only top 10 cause of
death in the United States that lacks disease‐altering treatments. It is a complex disorder …

Age-related macular degeneration (AMD) is the leading cause of vision loss in developed
countries. While linked to genetic polymorphisms in the complement pathway, there are …

mtDNA is transmitted through the maternal line and its sequence variability, which is
population specific, is assumed to be phenotypically neutral. However, several studies have …

Double-stranded DNA-specific cytidine deaminase (DddA) base editors hold great promise
for applications in bio-medical research, medicine, and biotechnology. Strict sequence …

Abstract Background Mitochondrial DNA (mtDNA) is important for energy production as it
encodes some of the key genes of electron transfer chain, where the majority of cellular …