Background Genetic alterations of somatic cells can drive non-malignant clone formation
and promote cancer initiation. However, the link between these processes remains unclear …

Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the third
leading cause of cancer-related deaths worldwide. Liver resection or liver transplantation is …

Tyrosine kinase inhibitors (TKI) play a pivotal role in the treatment of non-small-cell lung
cancer (NSCLC) with mutations in epidermal growth factor receptor (EGFR) and …

Causal discovery is becoming a key part in medical AI research. These methods can
enhance healthcare by identifying causal links between biomarkers, demographics …

Background Neuroblastoma is the most common malignancy in infancy, accounting for 15%
of childhood cancer deaths. Outcome for the high-risk disease remains poor. DNA …

PURPOSE A combination of fluorouracil, leucovorin, and oxaliplatin (FOLFOX) is the
standard for adjuvant therapy of resected early-stage colon cancer (CC). Oxaliplatin leads to …

Malignant sweat gland tumours are rare, with the most common form being Eccrine
porocarcinoma (EP). To investigate the mutational landscape of EP, we performed whole …

Cancers are mainly caused by somatic genomic alterations (SGAs) that perturb cellular
signaling systems and eventually activate oncogenic processes. Therefore, understanding …

Metabolism reprogramming within the tumor microenvironment (TME) can have a profound
impact on immune cells. Identifying the association between metabolic phenotypes and …

Simple Summary Knowledge extraction from cancer genomic studies is continuously
challenged by the fast-growing technological advances generating high-dimensional data …