As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Malignant pleural mesothelioma (MPM) is a highly lethal form of pleural cancer
characterized by a scarcity of effective therapeutic interventions, resulting in unfavorable …

Phosphoinositides are essential signaling molecules. The PI5P4K family of
phosphoinositide kinases and their substrates and products, PI5P and PI4, 5P2 …

Atherosclerosis is a chronic inflammatory disease and the pathological basis of many fatal
cardiovascular diseases. Macrophages, the main inflammatory cells in atherosclerotic …

The Hippo signaling pathway and its downstream effector YAP play a central role in cell
proliferation. Dysregulation of the Hippo pathway triggers YAP hyperactivation, thereby …

Compared to advancements in single-cell proteomics, phosphoproteomics sensitivity has
lagged behind due to low abundance, complex sample preparation, and substantial sample …

Head and neck squamous cell carcinoma (HNSCC) represents a highly prevalent and
deadly malignancy worldwide. The prognosis for locoregionally advanced HNSCC has not …

Simple Summary Head and Neck Squamous Cell Carcinoma (HNSCC) is a major threat to
public health around the world. Its occurrence is linked to genetic events and environmental …

Protein–protein interactions (PPIs) regulate signalling pathways and cell phenotypes, and
the visualization of spatially resolved dynamics of PPIs would thus shed light on the …