The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Role of interleukin-10 in acute brain injuries

JM Garcia, SA Stillings, JL Leclerc, H Phillips… - Frontiers in …, 2017 - frontiersin.org
Interleukin-10 (IL-10) is an important anti-inflammatory cytokine expressed in response to
brain injury, where it facilitates the resolution of inflammatory cascades, which if prolonged …

Traumatic axonal injury: mechanisms and translational opportunities

CS Hill, MP Coleman, DK Menon - Trends in neurosciences, 2016 - cell.com
Traumatic axonal injury (TAI) is an important pathoanatomical subgroup of traumatic brain
injury (TBI) and a major driver of mortality and functional impairment. Experimental models …

[HTML][HTML] Blood-based biomarkers of inflammation in mild traumatic brain injury: A systematic review

K Visser, M Koggel, J Blaauw, HJ van der Horn… - Neuroscience & …, 2022 - Elsevier
Abstract VISSER, K., M. Koggel, J. Blaauw, HJvd Horn, B. Jacobs, and Jvd Naalt. Blood
based biomarkers of inflammation in mild traumatic brain injury: A systematic review …

Inflammatory reaction after traumatic brain injury: therapeutic potential of targeting cell–cell communication by chemokines

S Gyoneva, RM Ransohoff - Trends in pharmacological sciences, 2015 - cell.com
Traumatic brain injury (TBI) affects millions of people worldwide every year. The primary
impact initiates the secretion of pro-and anti-inflammatory factors, subsequent recruitment of …

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

MC Morganti-Kossmann, BD Semple, SC Hellewell… - Acta …, 2019 - Springer
This review recounts the definitions and research evidence supporting the multifaceted roles
of neuroinflammation in the injured brain following trauma. We summarise the literature …

Call off the dog (ma): M1/M2 polarization is concurrent following traumatic brain injury

JM Morganti, LK Riparip, S Rosi - PloS one, 2016 - journals.plos.org
Following the primary mechanical impact, traumatic brain injury (TBI) induces the
simultaneous production of a variety of pro-and anti-inflammatory molecular mediators …

Microglia activation as a biomarker for traumatic brain injury

DG Hernandez-Ontiveros, N Tajiri, S Acosta… - Frontiers in …, 2013 - frontiersin.org
Traumatic brain injury (TBI) has become the signature wound of wars in Afghanistan and
Iraq. Injury may result from a mechanical force, a rapid acceleration-deceleration movement …

Anaphylaxis: clinical patterns, mediator release, and severity

SGA Brown, SF Stone, DM Fatovich, SA Burrows… - Journal of allergy and …, 2013 - Elsevier
Background Prospective human studies of anaphylaxis and its mechanisms have been
limited, with few severe cases or examining only 1 or 2 mediators. Objectives We wanted to …