Almost two-thirds of patients with severe traumatic brain injury (TBI) develop some form of
hemostatic disturbance, which contributes to poor outcome. While the initial head injury …

Traumatic brain injury is a multifaceted condition that encompasses a spectrum of injuries:
contusions, axonal injuries in specific brain regions, edema, and hemorrhage. Brain injury …

Background Fibrinogen may play an important role in the survival of trauma patients;
however, its role in traumatic brain injury (TBI) and its correlation with disease prognosis …

Background Traumatic brain injury (TBI) is the main cause of death and severe disability in
young adults worldwide. Progressive hemorrhage (PH) worsens the disease and can cause …

BACKGROUND The coagulopathy of traumatic brain injury (TBI) remains poorly understood.
Contradictory descriptions highlight the distinction between systemic and local coagulation …

Posttraumatic coagulopathy involves disruption of both the coagulation and fibrinolytic
pathways secondary to tissue damage, hypotension, and inflammatory upregulation. This …

Despite improvements in medical triage and tertiary care, traumatic brain injury (TBI)
remains associated with significant morbidity and mortality. Almost two-thirds of patients with …

Background Traumatic brain injury (TBI) in combination with shock has been associated with
hypocoagulability. However, recent data suggest that TBI itself can promote a systemic …

BACKGROUND Impaired coagulation is associated with elevated risk of mortality in trauma
patients. Prior studies have demonstrated increased mortality in patients with …

Background Coagulopathy in traumatic brain injury (TBI) occurs frequently and is associated
with poor outcomes. Conventional coagulation assays (CCA) traditionally used to diagnose …