This article reviews the molecular structure, expression pattern, physiological function,
pathological roles and molecular mechanisms of Twist1 in development, genetic disease …

Embryogenesis is regulated by a number of complex signaling cascades, which are critical
for normal development. One such pathway begins with a secreted protein called “SONIC …

Twist1, a basic helix–loop–helix transcription factor, promotes breast tumor cell epithelial–
mesenchymal transition (EMT), invasiveness, and metastasis. However, the mechanisms …

Epithelial mesenchymal transition (EMT) has long been associated with breast cancer cell
invasiveness and evidence of EMT processes in clinical samples is growing rapidly …

Aggressive cancer phenotypes are a manifestation of many different genetic alterations that
promote rapid proliferation and metastasis. In this study, we show that stable overexpression …

To explore the basis of metastasis, we compared the human breast cancer lines MCF-7 and
MDA-MB453, which have low invasive ability, with their sublines MCF7-I4 and MDA-MB453 …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

The general requirement to induce mesoderm and allocate cells into different mesodermal
tissues such as body muscle or heart is common in many animal embryos. Since the …

Twist1 and Twist2 are highly conserved members of the Twist subfamily of bHLH proteins
responsible for the transcriptional regulation of the developmental programs in …

The role of estrogen receptor-α (ER) in breast cancer development, and as a primary clinical
marker for breast cancer prognosis, has been well documented. In this study, we identified …