Hydroxymethylation and its potential implication in DNA repair system: a review and future perspectives

A Shukla, M Sehgal, TR Singh - Gene, 2015 - Elsevier
Abstract The 5-hydroxymethylcytosine (5-hmC) is known to exist as a predictive indicator for
a variety of cancers, neurological abnormalities and other perilous diseases. The precursor …

An integrative-omics approach to identify functional sub-networks in human colorectal cancer

RK Nibbe, M Koyutürk, MR Chance - PLoS computational biology, 2010 - journals.plos.org
Emerging evidence indicates that gene products implicated in human cancers often cluster
together in “hot spots” in protein-protein interaction (PPI) networks. Additionally, small sub …

Novel structural and functional impact of damaging single nucleotide polymorphisms (SNPs) on human SMYD2 protein using computational approaches

AK Yadav, TR Singh - Meta Gene, 2021 - Elsevier
Complex disease-associated single-nucleotide polymorphisms (SNPs) can create, destroy,
or modify protein-coding sites. Cancer-associated genes have SNPs that affect gene …

An integrative approach for mapping differentially expressed genes and network components using novel parameters to elucidate key regulatory genes in colorectal …

M Sehgal, R Gupta, A Moussa, TR Singh - Plos one, 2015 - journals.plos.org
For examining the intricate biological processes concerned with colorectal cancer (CRC), a
systems biology approach integrating several biological components and other influencing …

Systems biology approach for mutational and site-specific structural investigation of DNA repair genes for xeroderma pigmentosum

M Sehgal, TR Singh - Gene, 2014 - Elsevier
Xeroderma pigmentosum (XP) is a rare genetic skin disorder caused due to the extreme
sensitivity for ultraviolet (UV) radiations. On its exposure, DNA acquires damages leading to …

Computational studies to explore the role of MSI associated DNA mismatch repair mechanisms in HNPCC through expression and interaction data

S Behl, A Sharma, P Suravajhala… - International Journal of …, 2020 - inderscienceonline.com
Microsatellite instability (MSI) is an error mechanism associated with DNA mismatch repair
(MMR) system constituting a set of genes. If MMR fails, MSI may lead to various forms of …

Studies on DNA Repair Mechanism and Non-Small Cell Lung Cancer

N Khan, TR Singh - 2023 - ir.juit.ac.in
Human beings are exposed to a variety of DNA damaging compounds on a regular basis,
which can have an impact on their health and affect disease states. On the other hand, DNA …

Fundamental and Best Practices for Protein Annotations

TR Singh, P Suravajhala - Bioinformatics and Computational Biology - taylorfrancis.com
During the last two decades, bioinformatics has seen contemporaneous growth with
massive genomic and proteomic data. A myriad of tools and servers have also been …

[PDF][PDF] Market Research on Prostate Cancer Disease Overview, Epidemiology, and Market Assessment

D Saklani, TR Singh, R Kumar - 2022 - ir.juit.ac.in
During the course of this project, I have been working as an Associate Analyst in the Market
Analytics and Forecasting team at DelveInsight Business Research LLP which is a business …

Modeling and Simulation studies of DNA repair genes MLH1, MSH2, MSH6, PMS1, PMS2 with reference to HE4 gene

T Katoch, PK Thakur, TR Singh - 2017 - ir.juit.ac.in
The two most important components of our project are modeling and simulation of the genes
involved in the endometrial and ovarian cancer. The bottom up approach was used starting …