Transforming growth factor-β (TGF-β), a prototype of multifunctional cytokine, is a key
regulator of extracellular matrix (ECM) assembly and remodeling. Specifically, TGF-β …

The biological response to implanted biomaterials in mammals is a complex series of events
that involves many biochemical pathways. Shortly after implantation, fibrinogen and other …

Objectives Examine whether osteoarthritis (OA) progression can be delayed by
halofuginone in anterior cruciate ligament transection (ACLT) rodent models. Methods 3 …

A central challenge for improving autoimmune therapy is preventing inflammatory pathology
without inducing generalized immunosuppression. T helper 17 (TH17) cells, characterized …

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic
options. Tartrate-resistant acid phosphatase 5 (ACP5) performs a variety of functions …

Halofuginone is an analog of febrifugine—an alkaloid originally isolated from the plant
Dichroa febrifuga. During recent years, halofuginone has attracted much attention because …

Hepatic fibrosis is a complex mechanism defined by the net deposition of the extracellular
matrix (ECM) owing to liver injury caused by multiple etiologies such as viral hepatitis and …

Abstract The trans-2, 3-disubstituted piperidine, quinazolinone-containing natural product
febrifugine (also known as dichroine B) and its synthetic analogue, halofuginone, possess …

Fibrosis is a known feature of dystrophic muscles, particularly the diaphragm, in the mdx
mouse. In this study we evaluated the effect of halofuginone, a collagen synthesis inhibitor …

The effect of halofuginone (Halo) on established fibrosis in older mdx dystrophic muscle was
investigated. Mice (8 to 9 mo) treated with Halo (or saline in controls) for 5, 10, or 12 wk were …