Despite recent advances in understanding the causes of epilepsy, especially the genetic,
comprehending the biological mechanisms that lead to the epileptic phenotype remains …

Alzheimer's disease (AD) is the commonest neurodegenerative disease with slow
progression. Pieces of evidence suggest that the GABAergic system is impaired in the early …

In humans, tissue injury and depression can both cause pain hypersensitivity, but whether
this involves distinct circuits remains unknown. Here, we identify two discrete glutamatergic …

Epileptic seizures are widely regarded to occur as a result of the excitation-inhibition
imbalance from a neuro-centric view. Although astrocyte-neuron interactions are …

In mammals, many organs lack robust regenerative abilities. Lost cells in impaired tissue
could potentially be compensated by converting nearby cells in situ through in vivo …

Seizures can emerge from multiple or large foci in temporal lobe epilepsy, complicating
focally targeted strategies such as surgical resection or the modulation of the activity of …

The medial septum (MS), as part of the basal forebrain, supports many physiological
functions, from sensorimotor integration to cognition. With often reciprocal connections with …

Epilepsy, one of the most severe neurological diseases, is characterized by abrupt recurrent
seizures. Despite great progress in the development of antiseizure drugs (ASDs) based on …

Objective Unidentified mechanisms largely restrict the viability of effective therapies in
pharmacoresistant epilepsy. Our previous study revealed that hyperactivity of the subiculum …

Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with
neuronal hyperexcitability. Apart from the classical imbalance between excitatory …