Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

Accumulating evidence has indicated that sirtuins are key components of diverse
physiological processes, including metabolism and aging. Sirtuins confer protection from a …

Mammalian cells use a specialized and complex machinery for the removal of altered
proteins or dysfunctional organelles. Such machinery is part of a mechanism called …

Abstract Background Long noncoding RNA HULC is highly up-regulation in human
hepatocellular carcinoma (HCC). However, the functions of HULC in hepatocarcinogenesis …

Macroautophagy (autophagy herein) is a cellular stress response and a survival pathway
that is responsible for the degradation of long-lived proteins, protein aggregates, as well as …

Background: The mammalian circadian clock and its associated clock genes are
increasingly been recognized as critical components for a number of physiological and …

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Placental insufficiency leading to intrauterine growth restriction (IUGR) demonstrates
perturbed gene expression affecting placental angiogenesis and nutrient transfer from …

Colorectal cancer (CRC) is the most common malignant tumor occurred in digestive system.
However, the prognosis of CRC patients is poor. Therefore, it is urgent to illuminate the …

Alzheimer's Disease (AD) is the most common cause of dementia in the elderly.
Centenarians–reaching the age of> 100 years while maintaining good cognitive skills …