Investigations on the impact of chemicals on the environment and human health have led to
the development of an exposome concept. The exposome refers to the totality of exposures …

Tobacco smoking causes not only lung cancer but also cancer of the oral and nasal cavities,
oesophagus, larynx, pharynx, pancreas, liver, kidney, stomach, urinary tract and cervix …

Formaldehyde (FA) is a high-volume production chemical manufactured worldwide to which
many people are exposed to both environmentally and occupationally. FA was recently …

Abstract Cytochrome P-450 (CYP) 1A1 plays a key role in phase I metabolism of polycyclic
aromatic hydrocarbons and in estrogen metabolism. It is expressed predominantly in …

Objectives were to investigate prospectively the ability of DNA adducts to predict cancer and
to study the determinants of adducts, especially air pollutants. DNA adducts were measured …

Formaldehyde (FA) is a commonly used chemical in anatomy and pathology laboratories as
a tissue preservative and fixative. Because of its sensitising properties, irritating effects and …

Abstract Benzo (a) pyrene [B (a) P] diolepoxide (BPDE)-DNA adducts were measured in the
leukocytes of 41 healthy smokers using high-performance liquid chromatography coupled …

The distribution of polymorphisms related to glutathione S-transferases (GST) has been
described in different populations, mainly for white individuals. We evaluated the distribution …

In addition to the well-known link between smoking and lung cancer, large epidemiological
studies have shown a relationship between smoking and cancers of the nose, oral cavity …

It is important to identify the potential genetic-susceptible factors that are able to modulate
individual responses to exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) …