Vitamin D and its potential interplay with pain signaling pathways

AM Habib, K Nagi, NB Thillaiappan… - Frontiers in …, 2020 - frontiersin.org
About 50 million of the US adult population suffer from chronic pain. It is a complex disease
in its own right for which currently available analgesics have been deemed woefully …

[HTML][HTML] The effect of vitamin D supplementation on rheumatoid arthritis patients: a systematic review and meta-analysis

Y Guan, Y Hao, Y Guan, H Bu, H Wang - Frontiers in Medicine, 2020 - frontiersin.org
Objective Observational studies have shown that vitamin D levels are inversely related to
rheumatoid arthritis activity, yet evidence from population interventions remains inconsistent …

Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy

B Lin, Y Wang, P Zhang, Y Yuan, Y Zhang… - The journal of headache …, 2020 - Springer
Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-
term devastating physical and psychological damage. Therefore, it is urgent to identify an …

Non‐drug pain relievers active on non‐opioid pain mechanisms

N Marchesi, S Govoni, M Allegri - Pain Practice, 2022 - Wiley Online Library
This review is aimed to summarize the pain‐relieving effect of non‐drug substances, mostly
prescribed as integrators in treatment of pain, including especially in chronic postoperative …

'Palliative-D'—Vitamin D Supplementation to Palliative Cancer Patients: A Double Blind, Randomized Placebo-Controlled Multicenter Trial

M Helde Frankling, C Klasson, C Sandberg… - Cancers, 2021 - mdpi.com
Simple Summary In this study, the effect of vitamin D supplementation on pain, infections,
fatigue and quality of life in patients with advanced cancer with verified vitamin D deficiency …

[HTML][HTML] Vitamin D and restless legs syndrome: a review of current literature

KLJ Cederberg, R Silvestri… - Tremor and other …, 2023 - ncbi.nlm.nih.gov
This review presents a detailed summary of the current literature regarding RLS and vitamin
D deficiency. To our knowledge it is the first review of its kind. We review the prevalence of …

[PDF][PDF] Relationship between vitamin D and nonspecific low back pain may be mediated by inflammatory markers

X Hao-Wei, Z Shu-Bao, Y Yu-Yang, H Chen… - Pain …, 2021 - painphysicianjournal.com
Background: Vitamin D deficiency has been linked to nonspecific low back pain (Ns-LBP);
however, the role of inflammation as a possible mediator between vitamin D levels and Ns …

Gut feelings: the microbiota-gut-brain axis on steroids

SY So, TC Savidge - American Journal of Physiology …, 2022 - journals.physiology.org
The intricate connection between central and enteric nervous systems is well established
with emerging evidence linking gut microbiota function as a significant new contributor to gut …

[HTML][HTML] Nutraceuticals: A source of benefaction for neuropathic pain and fibromyalgia

G Mishra, P Singh, M Molla, YS Yimer… - Journal of functional …, 2022 - Elsevier
Though both neuropathy and fibromyalgia are serious complications that cause widespread
pain, distinguishing between the two in order to provide adequate care is difficult. Metabolic …

Environmental factors and their impact on chronic pain development and maintenance

MB Sant'Anna, LF Kimura, WF Vieira, VO Zambelli… - Physics of Life …, 2024 - Elsevier
It is more than recognized and accepted that the environment affects the physiological
responses of all living things, from bacteria to superior vertebrates, constituting an important …