The ubiquitin system has become synonymous with the modification of lysine residues.
However, the substrate scope and diversity of the conjugation machinery have been …

The nematode Caenorhabditis elegans was chosen as a model genetic organism because
its attributes, chiefly its hermaphroditic lifestyle and rapid generation time, make it suitable …

Ubiquitination is initiated by transfer of ubiquitin (Ub) from a ubiquitin-activating enzyme (E1)
to a ubiquitin-conjugating enzyme (E2), producing a covalently linked intermediate (E2–Ub) …

Growth cone guidance and synaptic plasticity involve dynamic local changes in proteins at
axons and dendrites. The Dual-Leucine zipper Kinase MAPKKK (DLK) has been previously …

The formation of synapses in the vertebrate central nervous system is a complex process
that occurs over a protracted period of development. Recent work has begun to unravel the …

The precise patterns of neuronal assembly during development determine all functional
outputs of a nervous system; these may range from simple reflexes to learning, memory …

The brain changes in response to experience and altered environment. This neural plasticity
is largely mediated by morphological and functional modification of synapses, a process that …

The active zone is a specialized region of the presynaptic plasma membrane where synaptic
vesicles dock and fuse. In this study, we have investigated the cellular mechanism …

Chemical synapses are complex structures that mediate rapid intercellular signalling in the
nervous system. Proteomic studies suggest that several hundred proteins will be found at …

The formation, stabilization, and growth of synaptic connections are dynamic and highly
regulated processes. The glutamatergic neuromuscular junction (NMJ) in Drosophila grows …