Endometrial receptivity and embryo implantation processes are a major point of pregnancy
failure in many mammalian species, including humans. Although reproductive biology in …

Canine pregnancy relies on luteal steroidogenesis for progesterone (P4) production. The
canine placenta responds to P4, depending on the nuclear P4 receptor (PGR). This has …

Recurrent spontaneous abortion (RSA) is defined as the loss of two or more consecutive
intrauterine pregnancies that are clinically established early in pregnancy. To date, the …

Maternal-stroma derived decidual cells, the only cell population in the canine placenta
expressing the nuclear progesterone (P4) receptor (PGR), are crucial for the maintenance of …

Among domestic animal species, the reproductive biology of the dog belongs to the most
peculiar. This includes the conceptus-maternal communication and endocrine mechanisms …

To establish a functional placenta, its development needs adequate trophoblastic
invasiveness. The intricate and complex morphological and molecular aspects regulating …

In the domestic dog, placentation arises from central implantation, passing through a
transitional, yet important stage of choriovitelline placenta (yolk sac placenta), on the way to …

To date, the biological functions of P4 within the canine placenta have been attributed to
maternal stroma-derived decidual cells as the only placental cells expressing the nuclear P4 …

An altered oxytocin and progesterone receptor (OXTR and PGR, respectively) expression
was postulated in canine uterine inertia (UI), which is the lack of functional myometrial …

Relaxin (RLN) is a key hormone of pregnancy in mammals best known for its involvement in
connective tissue remodeling. In the domestic dog, placental RLN is the only known …