Mechanistic models have been used for centuries to describe complex interconnected
processes, including biological ones. As the scope of these models has widened, so have …

Agent-based models provide a flexible framework that is frequently used for modelling many
biological systems, including cell migration, molecular dynamics, ecology and epidemiology …

Background Influenza A virus is one of the leading causes of annual mortality. The emerging
of novel escape variants of the influenza A virus is still a considerable challenge in the …

Mathematical models provide a rational basis to inform how, where and when to control
disease. Assuming an accurate spatially explicit simulation model can be fitted to spread …

Traditionally, precision medicine involves classifying patients to identify subpopulations that
respond favorably to specific therapeutics. We pose precision medicine as a dynamic …

Healthy skeletal muscle undergoes repair in response to mechanically localised strains
during activities such as exercise. The ability of cells to transduce the external stimuli into a …

Sepsis, a manifestation of the body's inflammatory response to injury and infection, has a
mortality rate of between 28%-50% and affects approximately 1 million patients annually in …

Pathogenic microorganisms entail enormous problems for humans, livestock, and crop
plants. A better understanding of the different infection strategies of the pathogens enables …

Near-optimal control of dynamical systems with neural ordinary differential equations -
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Background Tuberculosis (TB) represents a worldwide cause of mortality (it infects one third
of the world's population) affecting mostly developing countries, including India, and recently …