Growth hormone (GH) and structurally related cytokines regulate a great number of
physiological and pathological processes. They do this by coupling their single …

Thrombopoietin (TPO) and its receptor, MPL, are the primary regulators of platelet
production and critical for hematopoietic stem cell (HSC) maintenance. Since TPO was first …

Mutations in the calreticulin gene (CALR) represented by deletions and insertions in exon 9
inducing a− 1/+ 2 frameshift are associated with a significant fraction of myeloproliferative …

Recurrent somatic mutations of calreticulin (CALR) have been identified in patients
harboring myeloproliferative neoplasms; however, their role in tumorigenesis remains …

Introduction Class I cytokines regulate key processes such as growth, lactation,
hematopoiesis, and immune function and contribute to oncogenesis. Although the …

Homodimeric class I cytokine receptors are assumed to exist as preformed dimers that are
activated by ligand-induced conformational changes. We quantified the dimerization of three …

Abstract Calreticulin (CALR)+ 1 frameshift mutations in exon 9 are prevalent in
myeloproliferative neoplasms. Mutant CALRs possess a new C-terminal sequence rich in …

The magnitude of CAR T cell expansion has been associated with clinical efficacy. Although
cytokines can augment CAR T cell proliferation, systemically administered cytokines can …

A well-functioning hematopoietic system requires a certain robustness and flexibility to
maintain appropriate quantities of functional mature blood cells, such as red blood cells and …

Driver mutations occur in Janus kinase 2 (JAK2), thrombopoietin receptor (MPL), and
calreticulin (CALR) in BCR-ABL1 negative myeloproliferative neoplasms (MPNs). From …