Autophagy is a lysosome-dependent intracellular degradation system required for various
physiological processes and can be dysregulated in human disease. To understand its …

Monitoring autophagic flux is necessary for most autophagy studies. The autophagic flux
assays currently available for mammalian cells are generally complicated and do not yield …

ABSTRACT Background The etiology of Parkinson's disease (PD) is only partially
understood despite the fact that environmental causes, risk factors, and specific gene …

Background VPS35 is part of the retromer complex and is responsible for the trafficking and
recycling of proteins implicated in autophagy and lysosomal degradation, but also takes part …

Cellular physiology is critically regulated by multiple signaling nexuses, among which cell
death mechanisms play crucial roles in controlling the homeostatic landscape at the tissue …

Abstract Mitochondrial Rho GTPase 1 (Miro1) protein is a well-known adaptor for
mitochondrial transport and also regulates mitochondrial quality control and function …

Thymic stromal cells (TSCs) are critical regulators of T cell tolerance, but their basic biology
has remained under-characterized because they are relatively rare and difficult to isolate …

Single cell-based analysis of macroautophagy/autophagy is largely achieved through the
use of fluorescence microscopy to detect autophagy-related proteins that associate with …

Understanding the impact of viral pathogens on the human central nervous system (CNS)
has been challenging due to the lack of viable human CNS models for controlled …

Autophagy is important for many physiological processes; and disordered autophagy can
contribute to the pathogenesis of a broad range of systemic disorders. C. elegans is a useful …