1. INTRODUCTION The length of straightened-out DNA in a single cell is nearly 2 m. In
mammalian cells, the nucleus has a diameter of approximately 6 μm and occupies about …

Acridine derivatives are interesting chemotherapeutic agents that were first used as
antibacterial and antiparasite agents. In this review we wish to concentrate our attention on …

Acridine derivatives constitute a class of compounds that are being intensively studied as
potential anticancer drugs. Acridines are well-known for their high cytotoxic activity; …

DNA topoisomerases are important cellular enzymes found in almost all types of living cells
(eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic …

Acridone based synthetic and natural products with inherent anticancer activity advancing
the research and generating a large number of structurally diversified compounds. In this …

Background: The acridine scaffold is of interest since its DNA affinity and intercalative
properties make it an important pharmacophore for the design of antitumor drugs targeting …

Frequent fungal infections in immunocompromised patients and mortality due to invasive
mycosis are important clinical problems. Opportunistic pathogenic Candida species remain …

Topoisomerase inhibitors have been in use clinically for the treatment of several diseases
for decades. Although those enzymes are significant molecular targets in antibacterial and …

The present study describes the synthesis of fifteen 2-(9-oxoacridin-10 (9H)-yl)-N-phenyl
acetamide derivatives (13a–o) through condensation of 2-chloro-N-phenyl acetamides (12a …

New unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of
tumor cell lines but also against human tumor xenografts in nude mice. Representative UA …