Scientists are becoming alarmed by the rise in drug-resistant bacterial and fungal strains,
which makes it more costly, time-consuming, and difficult to create new antimicrobials from …

Natural bioactive compounds from plants exhibit substantial pharmacological potency and
therapeutic value. However, the development of most plant bioactive compounds is …

Background: Traditional toxicity testing emphasizes animal models with growing concerns
regarding predictive capacity, throughput and ethics. Rapid innovation surrounding human …

Three previously undescribed pyrrolizidinone alkaloids, penicipyrrolizidinones A and B (1
and 2), possessing an unprecedented 2-methyl-2-(oct-6-enoyl) pyrrolizidin-3-one skeleton …

Owing to multiple reactive sites, such as an acidic α‐carbon and an isocyano group,
isocyanide esters can successfully participate in the synthesis of various five‐and six …

Pyrrolizidine alkaloids (PAs) are toxic compounds that occur naturally in certain plants,
however, there are many secondary pathways causing PA contamination of other plants …

Non-Small Cell Lung Cancer (NSCLC) holds a significant position globally among cancer
types. Alkaloids, which are natural compounds containing nitrogen atoms, are found in …