G protein coupled receptors (GPCRs) are a class of membrane proteins that sense
extracellular signals ranging from light to odorants and small molecules and activate …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

G protein–coupled receptor (GPCR) kinases (GRKs) and arrestins interact with agonist-
bound GPCRs to promote receptor desensitization and downregulation. They also trigger …

Some G protein-coupled receptor (GPCR) ligands act as “biased agonists” that preferentially
activate specific signaling transducers over others. Although GPCRs are primarily found at …

The common mechanisms by which members of the G protein–coupled receptor (GPCR)
family respond to neurotransmitters in the brain have been well studied. However, it is …

G protein-coupled receptors (GPCRs) and other membrane proteins are valuable drug
targets, and their dynamic nature makes them attractive systems for study with molecular …

Agonist-induced phosphorylation of G protein-coupled receptors (GPCRs) is a key
determinant for the binding and activation of multifunctional regulatory proteins known as β …

Le récepteur dopaminergique de type D2 (RD2) est un récepteur couplé à une protéine G
(RCPG) majoritairement exprimé au niveau du système nerveux central où il est largement …