Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Many features of the environment have been found to exert an important influence on
cardiovascular disease (CVD) risk, progression, and severity. Changes in the environment …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Nitric oxide (NO) is a key signalling molecule in the cardiovascular, immune and central
nervous systems, and crucial steps in the regulation of NO bioavailability in health and …

Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality. Reperfusion
strategies are the current standard therapy for AMI. However, they may result in paradoxical …

Based on the “free radical theory” of disease, researchers have been trying to elucidate the
role of oxidative stress from free radicals in cardiovascular disease. Considerable data …

Extracellular flux (XF) analysis has become a mainstream method for measuring
mitochondrial function in cells and tissues. Although this technique is commonly used to …

Cardiovascular diseases are the first leading cause of death and morbidity in developed
countries. The use of animal models have contributed to increase our knowledge, providing …

Over the past 2 to 3 decades, several phenomena have been identified that provide
powerful protection against myocardial infarction and other sequelae of …