Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous
system that preferentially targets the optic nerves and spinal cord. The clinical presentation …

Background Typical optic neuritis is often the presenting manifestation of multiple sclerosis
(MS). Its incidence in central Europe is 5 cases per 100 000 persons per year. Methods This …

Background The human monoclonal antibody opicinumab (BIIB033, anti-LINGO-1) has
shown remyelinating activity in preclinical studies. We therefore assessed the safety and …

Background Acute demyelinating optic neuritis, a common feature of multiple sclerosis, can
damage vision through neurodegeneration in the optic nerve and in its fibres in the retina …

Background Neuromyelitis optica (NMO) and relapsing-remitting multiple sclerosis (RRMS)
are difficult to differentiate solely on clinical grounds. Optical coherence tomography (OCT) …

Neuromyelitis optica spectrum disorders (NMOSD) are mostly relapsing inflammatory
disorders of the central nervous system (CNS). Optic neuritis (ON) is the first NMOSD-related …

Objective To evaluate the inter-rater reliability of semiautomated segmentation of spectral
domain optical coherence tomography (OCT) macular volume scans. Methods Macular OCT …

Idiopathic demyelinating optic neuritis (ON) most commonly presents as acute unilateral
vision loss and eye pain and is frequently associated with multiple sclerosis. Although …

Intraocular pressure (IOP) reduction is currently the only evidence‐based treatment strategy
for glaucoma. However, IOP control in some individuals is challenging. Despite optimal …

Abstract From the Section Editor: The next two installments in the JNO “Disease of the Year:
Multiple Sclerosis” series focus on lessons that can be learned form the afferent visual …