Chromosomal fragile sites are specific loci that preferentially exhibit gaps and breaks on
metaphase chromosomes following partial inhibition of DNA synthesis. Their discovery has …

Common fragile sites are large chromosomal regions that preferentially exhibit gaps or
breaks after DNA synthesis is partially perturbed. Fragile site instability in cultured cells is …

Since the first description of human fragile sites (FS) more than 40 years ago, a variety of
substances were reported to induce chromosomal breaks at non-random, breakage-prone …

One hundred DNA sequences from the mitochondrial cytochrome-b gene of 44 species of
deer mice (Peromyscus (sensu stricto), 1 of Habromys, 1 of Isthmomys, 2 of Megadontomys …

The study of common fragile sites has its roots in the early cytogenetic investigations of the
fragile X syndrome. Long considered an interesting component of chromosome structure …

Common fragile sites are regions showing site-specific gaps and breaks on metaphase
chromosomes after partial inhibition of DNA synthesis. Common fragile sites are normally …

The common fragile sites are large regions of genomic instability that are found in all
individuals and are hot spots for chromosomal rearrangements and deletions. A number of …

Aphidicolin-induced common fragile sites are site-specific gaps or breaks seen on
metaphase chromosomes after partial inhibition of DNA synthesis. These fragile sites were …

Recently, several common fragile sites (CFSs) have been cloned and characterized,
including the two most frequently observed in the human population, FRA3B and FRA16D …

The concentration of evolutionary breakpoints in primate karyotypes in some particular
regions or chromosome bands suggests that these chromosome regions are more prone to …